New Paper: Preview from Vivan Lobo (Dev Cell) (6.8.2026)

In this new Preview in Developmental Cell, postdoc Vivian Lobo and I set metabolic enzymes in the broader context of mRNA translation regulation: A moonlighting metabolic enzyme shines light on translation initiation. Metabolic enzymes can serve as gene regulators by binding RNA, but the functions of most enzyme-RNA interactions remain unclear: Sharable Preview Link.

In the current issue of Developmental Cell, Zhang et al. from Shan Gao’s lab reveal that the proline biosynthesis enzyme Δ1-pyrroline-5-carboxylate synthase (P5CS) inhibits oncogene translation by blocking the assembly of the pre-initiation complex: Paper.